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alterations in mood, including depression and anxiety

Meanwhile, correlation analysis between MANF level and clinical variables in ICC showed that high expression of MANF was associated with larger tumor diameter ( P = 0.026), TNM stage ( P = 0.000), and distant metastasis ( P = 0.017) (Supplementary Table 1)

Systematic meta-analyses have demonstrated that depression patients have significantly elevated serum IL-6, TNF-, and C-reactive protein (CRP) levels (Osimo et al., 2020)

3.3.1 The RSS-cysteine-GSH metabolic axis as a regulatory triad RSS regulation of DC function operates primarily through control of cysteine availability and GSH homeostasis, rather than solely through H 2 S signaling

Some patients may achieve adequate glycemic control or weight loss at this dose level, particularly those with mild metabolic dysfunction or those who are particularly sensitive to the medications effects